Ultimately the only cause for disease is abuse and improper use of our bodies and mind.

When we overuse our senses, don’t use them at all, or use them improperly, we bring ill health upon ourselves. It is for this reason, Archarya Charaka has stated the following:

The causes of disease relating to both mind and body are three-fold :
wrong utilization, non-utilization and excessive utilization
of time, mental faculties and objects of the sense organs.

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The 3-fold Cause of DiseasePinspiration via DoctorSashina.com